Yes. Depression may get worse or develop with meds used for schizophrenia.
Combination of drugs are commonly used.
It is a very delicate disease and like in any psychiatric illness, the treatment is based on symptoms only. One has to be very observant and cautious in monitoring symptoms.
Unfortunately follow up of people is poor and families get tired of convincing the patients to go to physician…or take the medications.
Some smart patients do self administer injectible drugs when they feel deterioration in their condition.