Re: Desktop Replacement Notebooks
Although I don't have Toshiba Qosmio, but I have a Toshiba Satellite that I used as a desktop replacement. I haven't had any problems with it at all, alhamdulillah.
The only problems I encountered were due to my own negligence where dust was built up in the fan and I accidentally broke a key (which was taken care of by the extended warranty). In addition to that, I've been pretty careless with it while carrying it around the house (ie. hitting the screen in the door on a number of occasions), but it's still working great and fine, alhamdulillah.
Toshiba, overall is very good for laptops and quite reliable as well. Toshiba is a lot better than HP & Compaq at least.
Read the reviews and go for it, insha'Allah.