I know people who have gone back to Pakistan. They are the ones who had come to US as a student. Completed their education. Got good jobs. Got Married. Had kids. And then after 3-5 years, packed up and went back to Pakistan and are now, masha allah, extremely happy with their choice and their lives. And no, they don't have anything bad to say about US either. They were very happy here and they are happier in Pakistan.
People make choices, and they all have different reasons for the choices they make. The most important thing is to be very clear in your mind on why you are making the decision. Be it for the sake of better Islamic upbringing of your kids, be it the sake of being with your parents in their old age, be it the sake of helping your country, be it for the life-style, be it for what ever reason... just be sure that you are able to figure exactly what are the pros of your decision.
Moving from US to Pakistan, you will invariably have certain draw-backs. The climate is warmer, the infrastructure is poor, bad traffic, meddling relatives, lowers salaries, etc. All these things are managable if you have strong reasons of why you really want to move back. As long as you are mentally prepared to face all the difficulties because you believe your reasons for moving back are stronger than the draw-backs you will not rue your decision. Pure idealism, without carefully evaluating all your options may result in a feeling of "oh! I made the wrong decision" later. I know a couple of families who tried to settle in Pakistan, gave up in 1-2 years and then moved back to US.
Depending on your skill set and education, you may find excellent work opportunities in Pakistan. Most private sector industries are run by foreign-trained managers and the work environment is as challenging, in most cases, as it is here. Especially in the IT and high-tech fields. The salaries are good, and are consistent with the cost of living. I have no idea what kind of family situation you have or what kind of life-style you will like to maintain... but basic expenditure is roughly as follows, assuming its a family with two kids and going to settle in a desirable location of a major city, like Lahore, Isb or Khi.
Rent: Approx Rs 20,000-30,000/month
Groceries: Rs 3,000-5,000/mo
School fee for kids: Rs 2,000-5,000/mo
Other assorted home expenses: Rs 5,000-15,000/mo
Car/utlities expenses: Rs 5,000-15,000/mo
You will probably end up buying a car, in cash, which should be about 500,000 to 1,300,000.
I would say if you are well-educated, and have a two years experience and have markatable skill-set, you should aim for a starting salary of approx Rs 50,000-100,000/mo.
These are all rough estimates, and you will need to massage them based on your own situation and life-style.