oh wow vacation. so where are you headed for?. Looking at the weather up north, you must be going down to the Caribbean, Hawaii or the Fiji Islands?. Are you going with your hubby or is it a Girls' night out wala chakkar? hain hain.
It's good for students or people who have time on their hands. What I would suggest is to go to hotwire.com and get the lowest fare for the flight & time that you want.
Then start your bid at priceline at say 50 dollars less than what hotwire is offering. ;-)
I have bought tickets thru priceline several times. I once got fully furnished accomodation in Minneapolis near airport (Homestead suites) for $29 a night.
But buying airline tickets www.hotwire.com probably is the best.